Laboratory Manager

Philadelphia, PA

Cabaletta Bio is focused on the discovery and development of T cell therapies for B cell-mediated autoimmune diseases. Cabaletta’s therapeutic platform produces highly selective autologous Chimeric AutoAntibody Receptor (CAAR) T cells that are designed to precisely bind and destroy only specific autoantibody-producing B cells while sparing normal antibody-producing B cells, which are essential for human health. The platform is based on the revolutionary Chimeric Antigen Receptor (CAR) T cell technology developed at the University of Pennsylvania that resulted in one of the first commercially-available CAR T cell products for the treatment of B cell malignancies. Cabaletta has an exclusive global licensing agreement and multiple sponsored research agreements with the University of Pennsylvania to develop the CAAR T technology to treat B cell-mediated autoimmune diseases. The Company’s lead therapeutic program is a potential treatment for a prototypical B cell-mediated autoimmune disease, mucosal pemphigus vulgaris (mPV), which is a rare skin disorder that causes painful blisters and sores on mucous membranes leading to severe and sometimes debilitating and life-altering effects.

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing a new type of therapy, where patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that success in the Cabaletta mission lies in the hands of individuals across every aspect of the company. To nurture this, we make an active commitment to the well-being and continuous growth of each person who joins our team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew

About the Position

Reporting to the VP of Research, we are seeking an experienced and motivated Lab Manager to set-up and manage newly established research facilities for the company. The position involves both technical and operational responsibilities.

Responsibilities include to:

  • Set-up and maintain operations of the lab, manage day-to-day activities, and coordinate meetings with internal and external partners.
  • Participate and coordinate involvement in daily lab tasks, including scheduling of experiments and equipment.
  • Oversee operation and maintenance of essential equipment, maintaining all service records and contracts.
  • Onboard new R&D scientists.
  • Manage inventory supply and act as primary resource for purchasing laboratory resources.
  • Develop, implement, and maintain laboratory guidelines and standard operating procedures, consistent with GLP requirements.
  • With support from the Cabaletta Compliance team, ensure compliance with local, state and federal safety regulations, participate in training personnel on lab safety, conduct, standards.
  • Contribute to various molecular biology and immunology assays, including data analysis and interpretation, as needed.

Required Qualifications

  • MS degree or higher with 5 + years of laboratory management or equivalent industry experience.
  • Direct involvement in starting up laboratory facilities within biologics development.
  • Knowledgeable of up-to-date GLP guidelines, and laboratory safety and training requirements.
  • Comfortable with molecular biology and immunological assays, including experience with cell culture, cell processing, flow cytometry, and cell based functional assays.
  • Highly organized and efficient, with a curiosity to be part of cutting-edge science.

Preferred Skills

  • Digital PCR, ELISA, cell culture, molecular biology techniques, state of the art sequencing technologies, and murine studies.

Our name – Cabaletta – is derived from the operatic term for the second part of an aria that is designed to highlight the technical expertise of the lead singer. While our company is not the first to develop chimeric T cells as therapies, we are the first to develop them in a way that leverages T cells to specifically eliminate only B cells that cause disease, while sparing healthy B cells. Utilizing the backbone of this core technology, we expect to advance our portfolio with a rapid and repetitive rhythm, similar to the rhythm that is typical of a cabaletta.

For more information, please visit or email directly to submit an application. Please include your CV along with the title of the position you are applying for.

Our most important asset is our people and we offer competitive benefits, PTO, and stock option plans.

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.