Sr. Director/VP of Translational Immunology

Philadelphia, PA

Cabaletta Bio is focused on the discovery and development of T cell therapies for B cell-mediated autoimmune diseases. Cabaletta’s therapeutic platform produces highly selective autologous Chimeric AutoAntibody Receptor (CAAR) T cells that are designed to precisely bind and destroy only specific autoantibody-producing B cells while sparing normal antibody-producing B cells, which are essential for human health. The platform is based on the revolutionary Chimeric Antigen Receptor (CAR) T cell technology developed at the University of Pennsylvania that resulted in one of the first commercially-available CAR T cell products for the treatment of B cell malignancies. Cabaletta has an exclusive global licensing agreement and multiple sponsored research agreements with the University of Pennsylvania to develop the CAAR T technology to treat B cell-mediated autoimmune diseases. The Company’s lead therapeutic program is a potential treatment for a prototypical B cell-mediated autoimmune disease, mucosal pemphigus vulgaris (mPV), which is a rare skin disorder that causes painful blisters and sores on mucous membranes leading to severe and sometimes debilitating and life-altering effects.

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing a new type of therapy, where patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that success in the Cabaletta mission lies in the hands of individuals across every aspect of the company. To nurture this, we make an active commitment to the well-being and continuous growth of each person who joins our team.  In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew

About the Position

Reporting to the Chief Medical Officer, the Sr. Director or VP of Translational Immunology will be responsible for the vision, strategy, and understanding of the mode of action for engineered T Cells in patient samples. This individual will engage in a coaching and team building style that fosters development of a highly motivated and high performing team.

Responsibilities include to:

  • Apply expertise in immunology drug discovery to influence overall Immunology Research strategy and patient efficacy progression.
  • Serve as Immunology research lead on cross-functional clinical project teams; working as a leader to design, plan, and deliver multiple individual projects via team and matrix management.
  • Provides key specifics on the mechanism of action, biomarker strategy and patient selection.
  • Carry out immunological profiling on patients for clinical study.
  • Author or contribute to clinical study report sections, regulatory submissions and updates, including (IND/CTDs, BLA, DSUR etc.) and abstracts/manuscripts for publication.
  • Work successfully with the Head of Analytics to establish analysis tools and methods for T-Cell product characterization in process, at formulation, and post patient infusion.
  • Establish and maintain visible and active engagement with key opinion leaders, professional societies, and academic institutions.
  • Manage and drive internal and external collaborations/alliances with immunology focused academic institutions and pharma/biotech companies.
  • Lead and manage daily activities in combination with a team of more junior level staff.

Required Qualifications

  • PhD, or equivalent experience, in immunology, pharmacology/drug discovery and/or associated aspects of autoimmunity; as evidenced by high impact peer-reviewed publications and a strong track record in the pharmaceutical industry.
  • 10 + years of research experience in industry drug development in immunology/autoimmunity.
  • Mastery of cell-based and in vitro, in vivo and ex vivo skills that can be applied to immunology research including multiparameter flow cytometry, human primary immune cell assays and disease relevant translational models.
  • Demonstrated knowledge of designing, implementing, and conducting studies for biomarker discovery, validation and qualification using human biomaterials to produce both timely and good quality data.
  • Thorough understanding of the clinical unmet medical need and positioning novel therapeutics in a fast-growing field.
  • Use of biomarkers and imaging as well as other techniques for translational application is required.
  • Previous team management experience, including the training of more junior level staff. 

Our name – Cabaletta – is derived from the operatic term for the second part of an aria that is designed to highlight the technical expertise of the lead singer. While our company is not the first to develop chimeric T cells as therapies, we are the first to develop them in a way that leverages T cells to specifically eliminate only B cells that cause disease, while sparing healthy B cells. Utilizing the backbone of this core technology, we expect to advance our portfolio with a rapid and repetitive rhythm, similar to the rhythm that is typical of a cabaletta.

For more information, please visit or email directly to submit an application. Please include your CV along with the title of the position you are applying for.

Our most important asset is our people and we offer competitive benefits, PTO, and stock option plans.

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.