Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Additional Information (Details)

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Commitments and Contingencies - Additional Information (Details)
 1 Months Ended 3 Months Ended 9 Months Ended
Oct. 31, 2018
Sep. 30, 2019
USD ($)
Faculty
Sep. 30, 2018
USD ($)
Sep. 30, 2019
USD ($)
Faculty
Sep. 30, 2018
USD ($)
Commitments and Contingencies [Line Items]          
Research and development expense   $ 3,220,000 $ 2,589,000 $ 8,645,000 $ 3,228,000
Operating Lease Agreement          
Commitments and Contingencies [Line Items]          
Operating lease, description       The lease term commenced in May 2019 and will expire in July 2022.  
Lease commencement period       2019-05  
Lease expiration period       2022-07  
Initial annual base rent       $ 261,000  
Percentage of annual increase of base rent       2.00%  
Rent expense   67,000   $ 110,000  
Research Service Agreement | Children’s Hospital of Philadelphia          
Commitments and Contingencies [Line Items]          
Research and development expense   0 162,000 201,000 162,000
Amounts due to agreement   0   0  
Penn Agreement          
Commitments and Contingencies [Line Items]          
Amounts due to agreement   0   0  
Obligation to be paid   2,000,000   $ 2,000,000  
Payment term       3 years  
Payment commencement date       2018-08  
License maintenance fee       $ 10,000  
Total milestone payments       20,000,000  
Sponsored Research Agreements | Penn          
Commitments and Contingencies [Line Items]          
Research and development expense   710,000 $ 710,000 2,131,000 1,247,000
Obligation to be paid   $ 8,500,000   $ 8,500,000  
Number of faculty member | Faculty   2   2  
Funding term       3 years  
Funding term end date       2021-04  
Sponsored Research Agreements | Penn | Prepaid Expenses and Other Current Assets          
Commitments and Contingencies [Line Items]          
Advance payments   $ 174,000   $ 174,000  
Sponsored Research Agreements | The Regents of the University of California          
Commitments and Contingencies [Line Items]          
Obligation to be paid   0   0  
Funding term end date 2020-10        
Master Translational Research Services Agreement          
Commitments and Contingencies [Line Items]          
Research and development expense   286,000   1,970,000 $ 0
Obligation to be paid   324,000   324,000  
Subscription and Technology Transfer Agreement          
Commitments and Contingencies [Line Items]          
Research and development expense   $ 250,000   $ 250,000