Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Additional Information (Details)

v3.22.2.2
Commitments and Contingencies - Additional Information (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Feb. 28, 2022
Jan. 31, 2021
Sep. 30, 2022
Sep. 30, 2021
Jun. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Commitments and Contingencies [Line Items]              
Research and development expense     $ 8,216 $ 8,169   $ 26,900 $ 22,575
Operating Lease Agreement              
Commitments and Contingencies [Line Items]              
Operating lease, description           The lease term commenced in May 2019 and was set to expire in July 2022.  
Lease commencement period           2019-05  
Lease expiration period 2025-06         2022-07  
Initial annual base rent $ 279         $ 261  
Percentage of annual increase of base rent 2.50%         2.00%  
Lease Amendment Period 35 months            
Rent expense     549   $ 69 $ 1,127 205
Wuxi Agreement | WuXi Advanced Therapies              
Commitments and Contingencies [Line Items]              
Lease expiration period           2024-01  
Lease Amended Period           2022-08  
Monthly fee included in minimum lease payment   $ 125   180   $ 810 300
Early termination fee     1,500     1,500  
Research Service Agreement | Children's Hospital of Philadelphia              
Commitments and Contingencies [Line Items]              
Research and development expense     0 $ 250   166 $ 822
Liability related to agreement     $ 480     $ 480