Our RESETTM clinical trials with CABA-201 (investigational CD19-CAR T cell therapy) in lupus and myositis are now recruiting.

Join Our Crew

Senior Research Associate, Analytical Development – QC Operator

Philadelphia, PA

About the Position

Cabaletta Bio (Nasdaq: CABA) is a clinical-stage biotechnology company focused on the discovery and development of engineered T cell therapies that have the potential to provide a deep and durable, perhaps curative, treatment for patients with autoimmune diseases. The CABA™ platform encompasses two strategies: the CARTA (chimeric antigen receptor T cells for autoimmunity) strategy, with CABA-201, a 4-1BB-containing fully human CD19-CAR T, as the lead product candidate being evaluated in the RESET™ (REstoring SElf-Tolerance) clinical trials in systemic lupus erythematosus, myositis, systemic sclerosis and generalized myasthenia gravis, and the CAART (chimeric autoantibody receptor T cells) strategy, with multiple clinical-stage candidates, including DSG3-CAART for mucosal pemphigus vulgaris and MuSK-CAART for MuSK myasthenia gravis. The expanding CABA™ platform is designed to develop potentially curative therapies that offer deep and durable responses for patients with a broad range of autoimmune diseases. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, visit  www.cabalettabio.com and follow us on LinkedIn and X (Twitter).

At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew.  /p>

We’re proud to be a Great Place to Work-Certified™ company! #GPTWcertified Check out what our employees say makes working here so great:  Working at Cabaletta Bio Inc | Great Place to Work®

Responsibilities Include

  • Perform quality control testing to evaluate lentiviral vectors, CAR-T / CAAR-T cells and stability samples generated by internal groups and external partners.
  • Assist to develop analytical methods for the characterization and release of lentiviral vectors and CAR-T / CAAR-T cells.
  • Assist to Identify and implement opportunities for analytical method improvement and participate optimization of existing analytical methods to enhance sensitivity and efficiency.
  • Perform method qualification studies in accordance with regulatory guidelines.
  • Perform general lab and equipment maintenance duties.
  • Participate in technical troubleshooting and problem investigation.
  • Prepare, evaluate, and present data internally to cross functional teams.
  • Prepare detailed and accurate documentation of experimental procedures, results, and conclusions.
  • Stay current with advances in analytical techniques and industry trends.

Required Qualifications

  • Bachelor’s or master’s degree in biology or closely related discipline, and with 1-3 years of experience.
  • Proficient in aseptic technique for cell culture and cell-based assays.
  • Experience in analytic techniques, including flow cytometry, qPCR/dPCR, or ELISA etc.
  • Flexible to support various analytical activities and to learn new techniques outside of existing field of expertise.
  • Experience with quality control programs for lentiviral vector and CAR-T product preferred.
  • Ability to work collaboratively in a fast-paced environment.
  • Highly organized and strong written and verbal communication skills.
  • Strong laboratory documentation practice with high scientific integrity.
  • Strong team orientation and passion for continuous self-development. 
  • Experience in the biotech industry or in a startup industrial setting is preferred. 


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How to Apply

Please click the link at the bottom of the posting to submit an application.

Benefits

Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.

Equal Opportunity Employer

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.