Our RESETTM clinical trials with CABA-201 (investigational CD19-CAR T cell therapy) in lupus, myositis, systemic sclerosis, myasthenia gravis, and pemphigus vulgaris are now recruiting.

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Senior Research Associate/ Associate Scientist, Translational Medicine

About the Position

Reporting to the Senior Scientist, Translational Medicine we are seeking an experienced, motivated, detail-oriented, and highly skilled Senior Research Associate/Associate Scientist within our Translational Medicine team. 

Under scientific and technical supervision, the individual will be primarily responsible for developing and performing a host of different molecular assays that will support our understanding of Cabaletta Bio’s cellular therapies investigated in various clinical trials. More specifically, the candidate will be utilizing Luminex based assays to evaluate serum antibody levels, dPCR to interrogate drug product concentration, and MSD (Meso Scale Discovery) to measure multiple serum biomarkers. As part of the Translational Medicine team, the individual must be able to perform qualified assays on clinical trial participant materials, adhering to internal compliance standards. 

Responsibilities Include

  • With guidance from a Senior Scientist, Translational Medicine, perform translational assays on clinical samples and potentially pre-clinical samples.
  • Perform qualified or validated molecular based assays (Luminex, dPCR, MSD etc.) on clinical samples to inform on cell product persistence, activity, and efficacy in humans.
  • Perform correlative molecular assays with close attention to detail and adhering to tight timelines at certain times.
  • Participate in generating, qualifying, and validating GLP-like assays and author corresponding SOPs, where applicable.
  • Interface heavily with the electronic lab notebook (eLN) system and sample management system; accurately capturing sample metadata and assay data in a timely manner, ensuring data integrity and protocol compliance using an eLN.
  • Maintain GDP-compliant and detailed records for clinical sample lifecycle (receipt, usage, inventory, etc.).
  • Involvement in clinical sample accessioning with close attention to metadata entry.
  • Opportunities to learn and perform cell-based assays such as flow cytometry and cell killing assays.
  • Excellent time-management skills and ability to manage multiple internal projects / workstreams simultaneously.
  • Perform lab associated tasks in accordance with GLP and Cabaletta Bio lab safety policies and SOPs.
  • Have a team-first mentality by maintaining laboratory space and contributing to weekly activities.

Required Qualifications

  • MS degree in Biology, Immunology, Engineering or related field or Bachelor’s degree with 2+ years of experience in an academic laboratory or the biotechnology industry is required.
  • Experience with molecular based assays such as Luminex, dPCR, and/or MSD.
  • Significant lab experience including aseptic technique, mammalian cell culture, human tissue handling, and plated cell-based assays.
  • Must be able to follow SOPs and follow good documentation practices (GDP).
  • Must be highly organized and efficient, able to work independently. Strong problem-solving skills are preferred.
  • Must be able to communicate clearly verbally and in writing.
  • Must have a desire to be part of a growing organization that uses cutting-edge science.
  • Strong team orientation and passion for continuous self-development.
  • Comfortable in a fast-paced small company environment and able to adjust workload based upon changing priorities.

Preferred Skills

  • Experience in protocol design, qualification, and SOP generation.
  • Experience with the Luminex platform.
  • Experience with the MSD platform.
  • Experience with a digital PCR platform.
  • Experience with clinical sample handling and inventory management is highly preferred.
  • Experience troubleshooting, qualifying, or validating molecular based assays.
  • Experience in the biotechnology industry or in a startup industrial setting.
  • Previous experience with GLP/GCP & ICH regulations.
  • Prior use of an electronic laboratory notebook system; involvement in system development is a plus.

Apply For This Job

How to Apply

Please click the link at the bottom of the posting to submit an application.

Benefits

Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.

Equal Opportunity Employer

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.