Our RESETTM clinical trials with CABA-201 (investigational CD19-CAR T cell therapy) in lupus and myositis are now recruiting.

Pipeline

Clinical-stage targeted cell therapy pipeline for autoimmune diseases

In certain autoimmune diseases, pathogenic B cells secrete autoantibodies, or antibodies that mistakenly target healthy host proteins, which are responsible for causing disease.

Advancing Innovative T Cell Therapy Candidates in Autoimmune Disease

We are targeting a portfolio of autoimmune diseases with our engineered T cell therapy candidates. Our lead Chimeric Antigen Receptor T cell for Autoimmunity (CARTA) candidate, CABA-201, is being advanced in the RESETTM (REstoring SElf-Tolerance) Phase 1/2 clinical trials in systemic lupus erythematosus, myositis, systemic sclerosis and generalized myasthenia gravis, with potential application in a broad portfolio of other autoimmune diseases in rheumatology, neurology, and other therapeutic areas.

Our Pipeline

CARTA CAART 2 CABA-201 DSG3-CAART 3 MuSK-CAART 3 C himeric A ntigen R eceptor T  cells for A utoimmunity 4-1BB CD19-CAR T C himeric A uto A ntibody R eceptor T  cells CABA™ Platform Program Indication IND cleared IND cleared Myositis (IIM, Idiopathic Inflammatory Myopathy) 1 Systemic Lupus Erythematosus (SLE) 1 MuSK Myasthenia Gravis Mucosal Pemphigus Vulgaris Multiple Undisclosed Indications Systemic Sclerosis (SSc) 1 Generalized Myasthenia Gravis (gMG) 1 Discovery Dermatomyositis Anti-Synthetase Syndrome Lupus Nephritis Non-Renal SLE AChR Antibody-Positive AChR Antibody-Negative Severe Skin Involvement Severe Organ Involvement Immune-Mediated Necrotizing Myopathy Preclinical Phase 1/2 Phase 2/3

1CABA-201 is being evaluated in separate clinical trials for myositis, SLE, SSc & gMG.
2Additional CAART pipeline candidates include PLA2R-CAART in preclinical stage for PLA2R membranous nephropathy, DSG3/1-CAART in discovery stage for mucocutaneous pemphigus vulgaris & 2 undisclosed targets in discovery stage.
3Currently being evaluated in a Phase 1 trial.

Chimeric Antigen Receptor T cells for Autoimmunity: CABA-201

We are developing CABA-201, a fully human CD19 chimeric antigen receptor (CAR) T cell therapy containing a 4-1BB co-stimulatory domain, for autoimmune diseases with high unmet need. The fully human CD19 binder has been clinically evaluated in a dual-CD19xCD22 CAR T in cancer through an investigator-initiated trial, where it has shown promising tolerability in ~20 patients. CABA-201 is designed to be given as a one-time infusion, with the potential to transiently, but fully, eliminate B cells, thus enabling a potential “immune system reset” and durable responses for patients with autoimmune disease. We are advancing CABA-201 in the RESETTM Phase 1/2 clinical trials in systemic lupus erythematosus, myositis, systemic sclerosis and generalized myasthenia gravis.

Learn about CABA-201