Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Additional Information (Details)

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Commitments and Contingencies - Additional Information (Details) - USD ($)
1 Months Ended 3 Months Ended
Feb. 28, 2022
Jan. 31, 2021
Mar. 31, 2022
Mar. 31, 2021
Commitments and Contingencies [Line Items]        
Research and development expense     $ 9,170,000 $ 6,556,000
Loss related to litigation settlement accrued     $ 0  
Operating Lease Agreement        
Commitments and Contingencies [Line Items]        
Operating lease, description     The lease term commenced in May 2019 and was set to expire in July 2022.  
Lease commencement period     2019-05  
Lease expiration period 2025-06   2022-07  
Initial annual base rent $ 279,000   $ 261,000  
Percentage of annual increase of base rent 2.50%   2.00%  
Lease Amendment Period 35 months      
Rent expense     $ 170,000 68,000
Wuxi Agreement | WuXi Advanced Therapies        
Commitments and Contingencies [Line Items]        
Lease expiration period   2024-01    
Rent expense     310,000 0
Monthly fee included in minimum lease payment   $ 125,000    
Early termination fee   $ 1,500,000    
Research Service Agreement | Children's Hospital of Philadelphia        
Commitments and Contingencies [Line Items]        
Research and development expense     166,000 $ 222,000
Liability related to agreement     480,000  
Research Service Agreement | Children's Hospital of Philadelphia | Accounts Payable        
Commitments and Contingencies [Line Items]        
Liability related to agreement     $ 333,000